XL413 (hydrochloride)
XL413 (hydrochloride)
CAS: 2062200-97-7
Molecular Formula: C14H13Cl2N3O2
XL413 (hydrochloride) - Names and Identifiers
XL413 (hydrochloride) - Physico-chemical Properties
| Molecular Formula | C14H13Cl2N3O2 |
| Molar Mass | 326.18 |
| In vitro study | XL413 inhibits the cell proliferation (IC 50 = 2685 nM), decreases cell viability (IC 50 = 2142 nM) and elicits the caspase 3/7 activity (EC 50 = 2288 nM) in Colo-205 cells. XL413 also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC 50 = 715 nM). XL413 shows cytotoxic effects on tumors, with IC 50 of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells. XL413 induces apoptosis in the Colo-205 cells, but not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC 50 of 22.7 nM. XL413 is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells. |
| In vivo study | XL413 (100 mg/kg, p.o.) shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) is well tolerated at all the doses, with no significant body weight loss. |
XL413 (hydrochloride) - References
| biological activity | XL413 hydrozolide is a potent, selective, ATP-competitive Cdc7 inhibitor, the IC50 value was 3.4 nM, while the IC50 values for CK2 and PIM1 were 215 and 42 nM, respectively, and the EC50 value for pMCM was 118 nM. |
Last Update：2024-04-09 20:49:11
